Dosage Derivation of Marbofloxacin in Broiler Chickens based on Pharmacokinetic-Pharmacodynamic Integration

Marbofloxacin, a veterinary–exclusive antimicrobial drug of third–generation fluoroquinolone class, exhibits wide spectrum activity against Gram-negative as well Gram-positive bacteria, and thus, is promising agent to treat susceptible bacterial infections in poultry. Therefore, the present study was conducted derive dosage regimen marbofloxacin based on results intravenous oral pharmacokinetic (PK) trial sixteen healthy broiler chickens. Plasma concentrations were measured by optimized in-house validated Ultra High Performance Liquid Chromatography (UHPLC) method. The PK parameters calculated from plasma versus time data non-compartmental analysis using ‘PK Solver 2.0’ software. Following administration at dose rate 5 mg/kg body weight, mean maximal concentration (Cmax: 2.193 µg/ml) achieved 1.68 h. Marbofloxacin showed long half-life (6.03 h), high volume distribution (2.64 L/Kg) good bioavailability (88.10 %). average ≥ 0.32 µg/ml maintained upto 12 h 0.10 24 Based values PK-PD integrated indices, it concluded that @ 5.0 be repeated h, would efficient common pathogens chickens having MIC ≤ 0.12 μg/ml.